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1
Olanzapine - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK532903/
Excretion: The half-life of olanzapine is approximately 30 hours (varies between 21 to 54 hours). Olanzapine is excreted primarily via the renal ...
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https://www.ncbi.nlm.nih.gov/books/NBK532903/
Excretion: The half-life of olanzapine is approximately 30 hours (varies between 21 to 54 hours). Olanzapine is excreted primarily via the renal ...
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2
Olanzapine Pharmacokinetics - Psychopharmacology Institute
https://psychopharmacologyinstitute.com/publication/olanzapine-pharmacokinetics-2159
It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Food does not ...
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https://psychopharmacologyinstitute.com/publication/olanzapine-pharmacokinetics-2159
It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Food does not ...
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3
Olanzapine: Uses, Interactions, Mechanism of Action - DrugBank
https://go.drugbank.com/drugs/DB00334
Olanzapine is mainly eliminated through metabolism and hence, only 7% of the eliminated drug can be found as the unchanged form. It is mainly excreted in the ...
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https://go.drugbank.com/drugs/DB00334
Olanzapine is mainly eliminated through metabolism and hence, only 7% of the eliminated drug can be found as the unchanged form. It is mainly excreted in the ...
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4
Olanzapine Pathway, Pharmacokinetics - PharmGKB
https://www.pharmgkb.org/pathway/PA166165056
Metabolism. The main circulating metabolites of olanzapine are desmethyl olanzapine and olanzapine-10- glucuronide [Article:26849777].
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https://www.pharmgkb.org/pathway/PA166165056
Metabolism. The main circulating metabolites of olanzapine are desmethyl olanzapine and olanzapine-10- glucuronide [Article:26849777].
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5
Olanzapine - Wikipedia
https://en.wikipedia.org/wiki/Olanzapine
Olanzapine ; Liver (direct glucuronidation and CYP1A2 mediated oxidation) · 33 hours, 51.8 hours (elderly) · Urine (57%; 7% as unchanged drug), faeces (30%).
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https://en.wikipedia.org/wiki/Olanzapine
Olanzapine ; Liver (direct glucuronidation and CYP1A2 mediated oxidation) · 33 hours, 51.8 hours (elderly) · Urine (57%; 7% as unchanged drug), faeces (30%).
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6
ZYPREXA - Olanzapine Tablets - Accessdata.fda.gov
https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020592s042s043,021086s022s023,021253s026lbl.pdf
It is eliminated extensively by first pass metabolism, with approximately. 40% of the dose metabolized before reaching the systemic circulation. Food does not ...
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020592s042s043,021086s022s023,021253s026lbl.pdf
It is eliminated extensively by first pass metabolism, with approximately. 40% of the dose metabolized before reaching the systemic circulation. Food does not ...
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7
Genetic Polymorphisms Associated With the ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fphar.2021.711940/full
Olanzapine is highly metabolized, since 7% of the drug is excreted as unchanged drug in urine (FDA, 1996). Its half-life (T1/2) ranges from 21 ...
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https://www.frontiersin.org/articles/10.3389/fphar.2021.711940/full
Olanzapine is highly metabolized, since 7% of the drug is excreted as unchanged drug in urine (FDA, 1996). Its half-life (T1/2) ranges from 21 ...
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8
Pharmacogenetics of olanzapine metabolism - Future Medicine
https://www.futuremedicine.com/doi/10.2217/pgs.13.120
OLA is metabolized by direct glucuronidation via UGT1A4 and UGT2B10 as well as by oxidative N-demethylation via CYP1A2, N-oxidation via FMO and ...
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https://www.futuremedicine.com/doi/10.2217/pgs.13.120
OLA is metabolized by direct glucuronidation via UGT1A4 and UGT2B10 as well as by oxidative N-demethylation via CYP1A2, N-oxidation via FMO and ...
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9
Olanzapine - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/olanzapine
Olanzapine is metabolized via glucuronidation and oxidation by CYP 450 1A2 with a mean half-life of 24 to 36 hours. Like clozapine, olanzapine's metabolism ...
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https://www.sciencedirect.com/topics/medicine-and-dentistry/olanzapine
Olanzapine is metabolized via glucuronidation and oxidation by CYP 450 1A2 with a mean half-life of 24 to 36 hours. Like clozapine, olanzapine's metabolism ...
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10
Association between olanzapine concentration and metabolic ...
https://www.nature.com/articles/s41537-022-00211-5
The metabolism of olanzapine mainly depends on CYP (cytochrome P450) 1A2 and CYP2D6 for oral intake and long-term injection administration. The ...
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https://www.nature.com/articles/s41537-022-00211-5
The metabolism of olanzapine mainly depends on CYP (cytochrome P450) 1A2 and CYP2D6 for oral intake and long-term injection administration. The ...
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11
Zyprexa, INN-olanzapine - European Medicines Agency |
https://www.ema.europa.eu/en/documents/scientific-discussion/zyprexa-epar-scientific-discussion_en.pdf
to 91 %) and extensive metabolism after oral dosing. Following i.m. administration in dogs and monkeys, absorption of olanzapine was complete and absolute ...
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https://www.ema.europa.eu/en/documents/scientific-discussion/zyprexa-epar-scientific-discussion_en.pdf
to 91 %) and extensive metabolism after oral dosing. Following i.m. administration in dogs and monkeys, absorption of olanzapine was complete and absolute ...
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12
In Vitro Characterization of the Human Liver Microsomal ...
https://dmd.aspetjournals.org/content/43/11/1806
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and related psychoses. The metabolism of OLZ is complex and ...
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https://dmd.aspetjournals.org/content/43/11/1806
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and related psychoses. The metabolism of OLZ is complex and ...
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13
The atypical antipsychotic olanzapine causes weight gain by ...
https://www.jci.org/articles/view/93362
Although it is one of the most commonly prescribed and effective AATPs, olanzapine causes the most weight gain and metabolic impairments in ...
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https://www.jci.org/articles/view/93362
Although it is one of the most commonly prescribed and effective AATPs, olanzapine causes the most weight gain and metabolic impairments in ...
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14
Olanzapine Pharmacology - News Medical
https://www.news-medical.net/health/Olanzapine-Pharmacology.aspx
Olanzapine is a lipophilic compound, which means that it needs to be metabolized to water-soluble molecules prior to its excretion via urine or bile.
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https://www.news-medical.net/health/Olanzapine-Pharmacology.aspx
Olanzapine is a lipophilic compound, which means that it needs to be metabolized to water-soluble molecules prior to its excretion via urine or bile.
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15
Comparative Effects of Chronic Treatment With Olanzapine ...
https://clinicaltrials.gov/ct2/show/NCT00287820
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism. The safety and scientific validity of this study ...
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https://clinicaltrials.gov/ct2/show/NCT00287820
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism. The safety and scientific validity of this study ...
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16
Olanzapine - bionity.com
https://www.bionity.com/en/encyclopedia/Olanzapine.html
Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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https://www.bionity.com/en/encyclopedia/Olanzapine.html
Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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17
Olanzapine (Zyprexa) - PsychDB
https://www.psychdb.com/meds/antipsychotics/second-gen-atypical/3-olanzapine
Smoking induces CYP1A2, which increases the metabolism of olanzapine. When the smoking stops or if a patient quits, this can lead to ...
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https://www.psychdb.com/meds/antipsychotics/second-gen-atypical/3-olanzapine
Smoking induces CYP1A2, which increases the metabolism of olanzapine. When the smoking stops or if a patient quits, this can lead to ...
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18
Metabolic Effects of Aripiprazole and Olanzapine Multiple ...
https://link.springer.com/article/10.1007/s12325-020-01566-w
Aripiprazole and olanzapine are atypical antipsychotics. ... olanzapine alter prolactin levels, lipid and glucose metabolism and hepatic, ...
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https://link.springer.com/article/10.1007/s12325-020-01566-w
Aripiprazole and olanzapine are atypical antipsychotics. ... olanzapine alter prolactin levels, lipid and glucose metabolism and hepatic, ...
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19
Atypical Antipsychotic Drug Olanzapine Deregulates Hepatic ...
https://www.karger.com/Article/Fulltext/494573
Hepatic cholesterol and triglyceride metabolism are crucial factors for maintaining the homeostasis of the lipid pool [13, 14]. Thus, the ...
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https://www.karger.com/Article/Fulltext/494573
Hepatic cholesterol and triglyceride metabolism are crucial factors for maintaining the homeostasis of the lipid pool [13, 14]. Thus, the ...
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20
Effects of Olanzapine on Bone Mineral Density, Glucose, and ...
https://www.hindawi.com/journals/ije/2019/1312804/
Aim. To explore whether olanzapine alters bone mineral density (BMD), glucose, and lipid metabolism in schizophrenia patients. Methods.
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https://www.hindawi.com/journals/ije/2019/1312804/
Aim. To explore whether olanzapine alters bone mineral density (BMD), glucose, and lipid metabolism in schizophrenia patients. Methods.
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21
Insulin and glucose metabolism with ... - APA PsycNet
https://psycnet.apa.org/record/2022-14159-001
A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the treatment of adults with ...
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https://psycnet.apa.org/record/2022-14159-001
A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the treatment of adults with ...
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22
The Metabolism of Atypical Antipsychotic Drugs: An Update
https://www.tandfonline.com/doi/pdf/10.3109/10401239909147064
KEY WORDS clozapine; olanzapine; quetiapine; risperidone; sertindole; ziprasidone; metabolism; pharmacokinetics; flavin-containing monooxygenases; ...
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https://www.tandfonline.com/doi/pdf/10.3109/10401239909147064
KEY WORDS clozapine; olanzapine; quetiapine; risperidone; sertindole; ziprasidone; metabolism; pharmacokinetics; flavin-containing monooxygenases; ...
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23
Olanzapine Monograph for Professionals - Drugs.com
https://www.drugs.com/monograph/olanzapine.html
Olanzapine reference guide for safe and effective use from the American Society of ... of factors that may result in slower metabolism of olanzapine (e.g., ...
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https://www.drugs.com/monograph/olanzapine.html
Olanzapine reference guide for safe and effective use from the American Society of ... of factors that may result in slower metabolism of olanzapine (e.g., ...
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24
Psychiatric Medication (Zyprexa) Can Alter Metabolism
https://www.drperlmutter.com/zyprexa-alters-metabolism/
These results suggest that the gut microbiome has a role in the cycle of metabolic dysfunction associated with olanzapine, and could represent a ...
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https://www.drperlmutter.com/zyprexa-alters-metabolism/
These results suggest that the gut microbiome has a role in the cycle of metabolic dysfunction associated with olanzapine, and could represent a ...
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25
Adverse Drug Reactions of Olanzapine, Clozapine and ... - MDPI
https://www.mdpi.com/1424-8247/15/6/749/pdf
CYP1A2 is pivotal in the metabolism of the APs olanzapine, clozapine, and loxapine, whose safety profile warrants caution. We aimed to shed some ...
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https://www.mdpi.com/1424-8247/15/6/749/pdf
CYP1A2 is pivotal in the metabolism of the APs olanzapine, clozapine, and loxapine, whose safety profile warrants caution. We aimed to shed some ...
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26
The metabolic effects of antipsychotic drugs - ScienceDaily
https://www.sciencedaily.com/releases/2011/07/110712094042.htm
Indeed, reduced body temperature after olanzapine treatment may generate many of the known side effects of this antipsychotic drug. The authors' ...
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https://www.sciencedaily.com/releases/2011/07/110712094042.htm
Indeed, reduced body temperature after olanzapine treatment may generate many of the known side effects of this antipsychotic drug. The authors' ...
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27
Metabolism of olanzapine. The chemical structure and ...
https://www.researchgate.net/figure/Metabolism-of-olanzapine-The-chemical-structure-and-metabolism-of-olanzapine-are-shown_fig1_49654593
... It is metabolized extensively within the liver undergoing glucuronidation (to yield the primary metabolic products), allylic hydroxylation, oxidation, and ...
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https://www.researchgate.net/figure/Metabolism-of-olanzapine-The-chemical-structure-and-metabolism-of-olanzapine-are-shown_fig1_49654593
... It is metabolized extensively within the liver undergoing glucuronidation (to yield the primary metabolic products), allylic hydroxylation, oxidation, and ...
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28
Effects of Olanzapine and Haloperidol on the Metabolic Status ...
https://academic.oup.com/jcem/article/95/1/118/2835184
Effects on glucose metabolism. These data indicate that olanzapine hampers insulin action on glucose disposal, whereas the effect of haloperidol was less clear.
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https://academic.oup.com/jcem/article/95/1/118/2835184
Effects on glucose metabolism. These data indicate that olanzapine hampers insulin action on glucose disposal, whereas the effect of haloperidol was less clear.
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29
Disrupted sphingolipid metabolism following acute clozapine ...
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0437-1
In contrast, olanzapine increased hepatic sphingomyelin levels (p < 0.05 vs controls). SGAs did not alter sphingolipid levels in the muscle.
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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0437-1
In contrast, olanzapine increased hepatic sphingomyelin levels (p < 0.05 vs controls). SGAs did not alter sphingolipid levels in the muscle.
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30
Effects of Olanzapine and Risperidone on Glucose ...
https://www.psychiatrist.com/jcp/effects/metabolic-disorder/effects-olanzapine-risperidone-glucose-metabolism/
Effects of Olanzapine and Risperidone on Glucose Metabolism and Insulin Sensitivity in Chronic Schizophrenic Patients With Long-Term ...
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https://www.psychiatrist.com/jcp/effects/metabolic-disorder/effects-olanzapine-risperidone-glucose-metabolism/
Effects of Olanzapine and Risperidone on Glucose Metabolism and Insulin Sensitivity in Chronic Schizophrenic Patients With Long-Term ...
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31
olanzapine (Rx) - Medscape Reference
https://reference.medscape.com/drug/zyprexa-relprevv-olanzapine-342979
Medscape - Schizophrenia, bipolar disorder-specific dosing for Zyprexa, ... PO qDay for patients with risk factors which may slow olanzapine metabolism (eg, ...
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https://reference.medscape.com/drug/zyprexa-relprevv-olanzapine-342979
Medscape - Schizophrenia, bipolar disorder-specific dosing for Zyprexa, ... PO qDay for patients with risk factors which may slow olanzapine metabolism (eg, ...
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32
Metabolism of the antipsychotic drug olanzapine by CYP3A43
https://www.docwirenews.com/condition-center/precision-medicine-in-prostate-cancer/precision-medicine-in-prostate-cancer-abstracts/metabolism-of-the-antipsychotic-drug-olanzapine-by-cyp3a43-4/
But until now there was no experimental evidence for the metabolism of olanzapine by the CYP3A43 enzyme.2. In the present study we provide this ...
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https://www.docwirenews.com/condition-center/precision-medicine-in-prostate-cancer/precision-medicine-in-prostate-cancer-abstracts/metabolism-of-the-antipsychotic-drug-olanzapine-by-cyp3a43-4/
But until now there was no experimental evidence for the metabolism of olanzapine by the CYP3A43 enzyme.2. In the present study we provide this ...
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33
Metabolic Drug Interactions with Newer Antipsychotics
https://bhdp.sccgov.org/sites/g/files/exjcpb716/files/metabolicDrugInteractionwNewerAntipsychotic.pdf
drug-metabolizing enzymes involved in their biotransformation, i.e. the cytochrome P450 (CYP) ... olanzapine is metabolized by multiple enzyme systems,.
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https://bhdp.sccgov.org/sites/g/files/exjcpb716/files/metabolicDrugInteractionwNewerAntipsychotic.pdf
drug-metabolizing enzymes involved in their biotransformation, i.e. the cytochrome P450 (CYP) ... olanzapine is metabolized by multiple enzyme systems,.
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34
zyprexa-pi.pdf - Eli Lilly and Company
https://pi.lilly.com/us/zyprexa-pi.pdf
ZYPREXA® (olanzapine) is an atypical antipsychotic indicated: ... metabolism of olanzapine (e.g., nonsmoking female patients ≥65 years of age), ...
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https://pi.lilly.com/us/zyprexa-pi.pdf
ZYPREXA® (olanzapine) is an atypical antipsychotic indicated: ... metabolism of olanzapine (e.g., nonsmoking female patients ≥65 years of age), ...
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35
KEGG DRUG: Olanzapine
https://www.genome.jp/entry/D00454
Metabolizing enzyme substrate. DG01892 CYP1A2 substrate. DG00898 Olanzapine D00454 Olanzapine DG01644 CYP2D6 substrate. DG00898 Olanzapine D00454 Olanzapine
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https://www.genome.jp/entry/D00454
Metabolizing enzyme substrate. DG01892 CYP1A2 substrate. DG00898 Olanzapine D00454 Olanzapine DG01644 CYP2D6 substrate. DG00898 Olanzapine D00454 Olanzapine
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36
Glucose Metabolism in Patients With Schizophrenia Treated ...
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/208155
Olanzapine treatment similarly resulted in elevated serum levels of insulin, in addition to weight gain and elevations of serum leptin and lipid ...
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https://jamanetwork.com/journals/jamapsychiatry/fullarticle/208155
Olanzapine treatment similarly resulted in elevated serum levels of insulin, in addition to weight gain and elevations of serum leptin and lipid ...
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37
Effects of Olanzapine on Brain Energy Metabolism Measured ...
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)30554-0/fulltext
Olanzapine blood levels were positively associated with endpoint NAD+/NADH levels (coeff=0.16, 95%CI=0.004,0.326). Treatment-related adverse ...
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https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)30554-0/fulltext
Olanzapine blood levels were positively associated with endpoint NAD+/NADH levels (coeff=0.16, 95%CI=0.004,0.326). Treatment-related adverse ...
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38
Olanzapine 5 mg tablets - Summary of Product Characteristics ...
https://www.medicines.org.uk/emc/product/3071/smpc
The starting dose and dose range need not be routinely altered for non-smokers relative to smokers. The metabolism of olanzapine may be induced by smoking.
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https://www.medicines.org.uk/emc/product/3071/smpc
The starting dose and dose range need not be routinely altered for non-smokers relative to smokers. The metabolism of olanzapine may be induced by smoking.
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39
The gut microbiome influences the bioavailability of ...
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00100-6/fulltext
The bioavailability of olanzapine, was significantly increased (1.8-fold) in rats that had undergone antibiotic-induced depletion of gut ...
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https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00100-6/fulltext
The bioavailability of olanzapine, was significantly increased (1.8-fold) in rats that had undergone antibiotic-induced depletion of gut ...
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40
Olanzapine metabolism and the significance of UGT1A448V ...
https://europepmc.org/article/med/21750471
Glucuronidation by the UDP-glucuronosyltransferase (UGT) family of enzymes is the major mode of olanzapine metabolism, and polymorphisms in these enzymes ...
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https://europepmc.org/article/med/21750471
Glucuronidation by the UDP-glucuronosyltransferase (UGT) family of enzymes is the major mode of olanzapine metabolism, and polymorphisms in these enzymes ...
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41
Clinical Pharmacogenetics of Olanzapine: with Focus on FMO ...
https://uu.diva-portal.org/smash/get/diva2:548339/FULLTEXT01.pdf
Keywords: olanzapine, pharmacogenetics, drug metabolism, schizophrenia, therapeutic drug monitoring, FMO1, FMO3, CYP1A2, UGT1A4.
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https://uu.diva-portal.org/smash/get/diva2:548339/FULLTEXT01.pdf
Keywords: olanzapine, pharmacogenetics, drug metabolism, schizophrenia, therapeutic drug monitoring, FMO1, FMO3, CYP1A2, UGT1A4.
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42
Olanzapine - chemeurope.com
https://www.chemeurope.com/en/encyclopedia/Olanzapine.html
Metabolism. Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by ...
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https://www.chemeurope.com/en/encyclopedia/Olanzapine.html
Metabolism. Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by ...
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43
Preliminary Examination of Olanzapine and Diet Interactions ...
https://symbiosisonlinepublishing.com/endocrinology-diabetes/endocrinology-diabetes12.php
(2014) Preliminary Examination of Olanzapine and Diet Interactions on Metabolism in a Female Macaque. J Endocrinol Diab 1(2): 9.
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https://symbiosisonlinepublishing.com/endocrinology-diabetes/endocrinology-diabetes12.php
(2014) Preliminary Examination of Olanzapine and Diet Interactions on Metabolism in a Female Macaque. J Endocrinol Diab 1(2): 9.
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44
Sex-differential effects of olanzapine vs. aripiprazole on ...
https://www.scielo.br/j/rpc/a/TY5LFKYdcLvpjx97v6pcVHn/?lang=en
Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia. XUE-MEI ZHOU.
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https://www.scielo.br/j/rpc/a/TY5LFKYdcLvpjx97v6pcVHn/?lang=en
Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia. XUE-MEI ZHOU.
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45
Zyprexa: Schizophrenia, Uses, Dosage, Side Effects ... - RxList
https://www.rxlist.com/zyprexa-drug.htm
Zyprexa is a prescription medicine used to treat the symptoms of schizophrenia and bipolar disorder ... Effect Of Olanzapine On Drug Metabolizing Enzymes.
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https://www.rxlist.com/zyprexa-drug.htm
Zyprexa is a prescription medicine used to treat the symptoms of schizophrenia and bipolar disorder ... Effect Of Olanzapine On Drug Metabolizing Enzymes.
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46
Pharmacokinetic Variability of Olanzapine - UiO - DUO
https://www.duo.uio.no/bitstream/handle/10852/34394/dravhandling-haslemo.pdf?sequence=1
This also means that most psychoactive drugs need to be metabolized to more water-soluble molecules prior to excretion via urine or bile. Drug metabolism is ...
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https://www.duo.uio.no/bitstream/handle/10852/34394/dravhandling-haslemo.pdf?sequence=1
This also means that most psychoactive drugs need to be metabolized to more water-soluble molecules prior to excretion via urine or bile. Drug metabolism is ...
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47
NEW ZEALAND DATASHEET - Medsafe
https://www.medsafe.govt.nz/profs/Datasheet/z/ZyprexatabZyprexazydiswafer.pdf
1 ZYPREXA 7.5 mg tablets are not marketed in New Zealand ... The metabolism of olanzapine may be induced by concomitant smoking (the clearance of.
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https://www.medsafe.govt.nz/profs/Datasheet/z/ZyprexatabZyprexazydiswafer.pdf
1 ZYPREXA 7.5 mg tablets are not marketed in New Zealand ... The metabolism of olanzapine may be induced by concomitant smoking (the clearance of.
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48
Metabolic effects of aripiprazole and olanzapine multiple
https://www.biorxiv.org/content/biorxiv/early/2020/07/30/2020.07.29.226209.full.pdf
Objectives: To evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepatic, hematological, ...
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https://www.biorxiv.org/content/biorxiv/early/2020/07/30/2020.07.29.226209.full.pdf
Objectives: To evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepatic, hematological, ...
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49
[PDF] Disposition and metabolism of olanzapine in mice, dogs ...
https://www.semanticscholar.org/paper/Disposition-and-metabolism-of-olanzapine-in-mice%2C-Mattiuz-Franklin/9971de4c063b4c8de574eda7e093e5f0a38bbac9
The pharmacokinetics, excretion, and metabolism of OLZ were studied in CD-1 mice, beagle dogs, and rhesus monkeys after a single oral and/or ...
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https://www.semanticscholar.org/paper/Disposition-and-metabolism-of-olanzapine-in-mice%2C-Mattiuz-Franklin/9971de4c063b4c8de574eda7e093e5f0a38bbac9
The pharmacokinetics, excretion, and metabolism of OLZ were studied in CD-1 mice, beagle dogs, and rhesus monkeys after a single oral and/or ...
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50
Fine Tuning the Use of Second Generation Antipsychotics
https://www.mentalhealthjournal.org/articles/fine-tuning-the-use-of-second-generation-antipsychotics.html
For example, a SGA such as olanzapine, quetiapine and ziprasidone ... How the drug is absorbed, distributed, metabolized and excreted is ...
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https://www.mentalhealthjournal.org/articles/fine-tuning-the-use-of-second-generation-antipsychotics.html
For example, a SGA such as olanzapine, quetiapine and ziprasidone ... How the drug is absorbed, distributed, metabolized and excreted is ...
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51
Atypical antipsychotic drugs deregulate the cholesterol ...
https://www.metabolismjournal.com/article/S0026-0495(21)00147-5/fulltext
Olanzapine accelerates the progression of atherosclerosis by deregulating hepatic lipid metabolism and aortic inflammation.
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https://www.metabolismjournal.com/article/S0026-0495(21)00147-5/fulltext
Olanzapine accelerates the progression of atherosclerosis by deregulating hepatic lipid metabolism and aortic inflammation.
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52
Insulin and glucose metabolism with olanzapine and a ...
https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=12661&context=open_access_pubs
A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the.
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https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=12661&context=open_access_pubs
A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the.
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53
Smoking and drug interactions - Australian Prescriber
https://www.nps.org.au/australian-prescriber/articles/smoking-and-drug-interactions
Cigarette smoking induces the metabolism of clozapine and olanzapine, resulting in lower plasma concentrations. ... The daily consumption of 7–12 ...
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https://www.nps.org.au/australian-prescriber/articles/smoking-and-drug-interactions
Cigarette smoking induces the metabolism of clozapine and olanzapine, resulting in lower plasma concentrations. ... The daily consumption of 7–12 ...
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54
Metabolism of the antipsychotic drug olanzapine by ... - Figshare
https://figshare.com/articles/journal_contribution/Metabolism_of_the_antipsychotic_drug_olanzapine_by_CYP3A43/19975894
1. Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. An intronic single nucleotide ...
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https://figshare.com/articles/journal_contribution/Metabolism_of_the_antipsychotic_drug_olanzapine_by_CYP3A43/19975894
1. Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. An intronic single nucleotide ...
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55
Second-Generation Neuroleptics - Johns Hopkins Guides
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787137/all/Second_Generation_Neuroleptics
Zyprexa. Olanzapine. Eli Lilly. Multiple generic companies ... Olanzapine: Metabolized by the liver via CYP1A2 and CYP2D6 and excreted ...
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https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787137/all/Second_Generation_Neuroleptics
Zyprexa. Olanzapine. Eli Lilly. Multiple generic companies ... Olanzapine: Metabolized by the liver via CYP1A2 and CYP2D6 and excreted ...
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56
High Doses of Drugs Extensively Metabolized by CYP3A4 ...
http://www.scielo.org.co/pdf/rcp/v49n2/0034-7450-rcp-49-02-84.pdf
patient with sensitivity to CYP3A4 induction should have nor- mal clozapine and olanzapine metabolism and, when taking carbamazepine, should have metabolism ...
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http://www.scielo.org.co/pdf/rcp/v49n2/0034-7450-rcp-49-02-84.pdf
patient with sensitivity to CYP3A4 induction should have nor- mal clozapine and olanzapine metabolism and, when taking carbamazepine, should have metabolism ...
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57
Atypical Antipsychotic Dosing: The Effect of Co-medication ...
https://ps.psychiatryonline.org/doi/10.1176/appi.ps.55.2.125
Initially, the pharmaceutical company marketing olanzapine suggested that the effects of carbamazepine on olanzapine metabolism could be ...
→ Check Latest Keyword Rankings ←
https://ps.psychiatryonline.org/doi/10.1176/appi.ps.55.2.125
Initially, the pharmaceutical company marketing olanzapine suggested that the effects of carbamazepine on olanzapine metabolism could be ...
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58
Meta-analysis: the effects of smoking on the disposition of two ...
https://bmjopen.bmj.com/content/4/3/e004216
Olanzapine is an atypical antipsychotic drug approved for the treatment of ... CYP1A2 accounts for approximately 50–60% of olanzapine metabolism.2.
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https://bmjopen.bmj.com/content/4/3/e004216
Olanzapine is an atypical antipsychotic drug approved for the treatment of ... CYP1A2 accounts for approximately 50–60% of olanzapine metabolism.2.
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59
Dosage and pharmacology of antipsychotics - UpToDate
https://www.uptodate.com/contents/image?imageKey=PSYCH/60624
Enzyme(s) inhibited; (refer to Notes)§
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https://www.uptodate.com/contents/image?imageKey=PSYCH/60624
Enzyme(s) inhibited; (refer to Notes)§
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60
Coffee, Cigarettes and Meds: What Are the Metabolic Effects?
https://www.psychiatrictimes.com/view/coffee-cigarettes-and-meds-what-are-metabolic-effects
On the other hand, the metabolism of clozapine (Clozaril) and olanzapine (Zyprexa) is mainly dependent on CYP1A2 and UGTs, and hence their ...
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https://www.psychiatrictimes.com/view/coffee-cigarettes-and-meds-what-are-metabolic-effects
On the other hand, the metabolism of clozapine (Clozaril) and olanzapine (Zyprexa) is mainly dependent on CYP1A2 and UGTs, and hence their ...
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61
Investigation of Clozapine and Olanzapine Reactive ...
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.0c00191
linked to oxidative metabolism resulting in the formation of reactive metabolites and subsequent covalent binding to biomolecules.
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https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.0c00191
linked to oxidative metabolism resulting in the formation of reactive metabolites and subsequent covalent binding to biomolecules.
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62
Antipsychotics and glucose metabolism: how brain and body ...
https://journals.physiology.org/doi/10.1152/ajpendo.00164.2018
In North America, the list of those that have been approved for clinical use presently includes risperidone, olanzapine (OLA), quetiapine, ziprasidone, ...
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https://journals.physiology.org/doi/10.1152/ajpendo.00164.2018
In North America, the list of those that have been approved for clinical use presently includes risperidone, olanzapine (OLA), quetiapine, ziprasidone, ...
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63
Olanzapine, 10 mg tablets - Arpimed
https://arpimed.am/en/olanzapine-10-mg-tablets/
Since Olanzapine is metabolised by CYP1A2, substances that can specifically induce or inhibit this isoenzyme may affect the pharmacokinetics of Olanzapine.
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https://arpimed.am/en/olanzapine-10-mg-tablets/
Since Olanzapine is metabolised by CYP1A2, substances that can specifically induce or inhibit this isoenzyme may affect the pharmacokinetics of Olanzapine.
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64
Olanzapine - WikEM
https://wikem.org/wiki/Olanzapine
Pharmacology · Half-life: Oral and short-acting IM: children 10 to 18 years ~37 hours, adult ~30 hours, 1.5 times greater in elderly. · Metabolism ...
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https://wikem.org/wiki/Olanzapine
Pharmacology · Half-life: Oral and short-acting IM: children 10 to 18 years ~37 hours, adult ~30 hours, 1.5 times greater in elderly. · Metabolism ...
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65
Histological Study of the Effects of Olanzapine on the Liver of ...
https://ejh.journals.ekb.eg/article_3824_3a3c80af6687d2424de83cb599b292ba.pdf
Introduction: Olanzapine is an atypical antipsychotic drug widely used in treatment ... p450, mainly CYP2C8 help in its oxidative metabolism.
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https://ejh.journals.ekb.eg/article_3824_3a3c80af6687d2424de83cb599b292ba.pdf
Introduction: Olanzapine is an atypical antipsychotic drug widely used in treatment ... p450, mainly CYP2C8 help in its oxidative metabolism.
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66
olanzapine or ZYPREXA Clinical Pharmacology Drug ...
https://www.wellrx.com/olanzapine/monographs/
Dosage adjustments may be necessary in patients who exhibit a combination of factors that may slow metabolism. Titrate dose with caution and close monitoring.
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https://www.wellrx.com/olanzapine/monographs/
Dosage adjustments may be necessary in patients who exhibit a combination of factors that may slow metabolism. Titrate dose with caution and close monitoring.
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67
Zyprexa Molecule-- Antipsychotic Drugs
https://www.worldofmolecules.com/drugs/zyprexa.htm
Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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https://www.worldofmolecules.com/drugs/zyprexa.htm
Olanzapine is metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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68
Olanzapine | Drugs - BNF - NICE
https://bnf.nice.org.uk/drugs/olanzapine/
View olanzapine information, including dose, uses, side-effects, ... or more factors present that might result in slower metabolism (e.g. females, elderly, ...
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https://bnf.nice.org.uk/drugs/olanzapine/
View olanzapine information, including dose, uses, side-effects, ... or more factors present that might result in slower metabolism (e.g. females, elderly, ...
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69
australian product information zyprexa (olanzapine) 1. name ...
https://www.guildlink.com.au/gc/ws/lilly/pi.cfm?product=lypzyprx
The active ingredient in ZYPREXA tablets is olanzapine. ... The metabolism of ZYPREXA may be induced by concomitant smoking (the clearance of.
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https://www.guildlink.com.au/gc/ws/lilly/pi.cfm?product=lypzyprx
The active ingredient in ZYPREXA tablets is olanzapine. ... The metabolism of ZYPREXA may be induced by concomitant smoking (the clearance of.
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70
Definition of olanzapine - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/olanzapine
... and vomiting caused by some cancer treatments. It is a type of antipsychotic and a type of monoamine antagonist. Also called Zyprexa and Zyprexa Zydis.
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https://www.cancer.gov/publications/dictionaries/cancer-terms/def/olanzapine
... and vomiting caused by some cancer treatments. It is a type of antipsychotic and a type of monoamine antagonist. Also called Zyprexa and Zyprexa Zydis.
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71
Effects of switching from olanzapine to aripiprazole on the ...
https://www.dovepress.com/effects-of-switching-from-olanzapine-to-aripiprazole-on-the-metabolic--peer-reviewed-fulltext-article-NDT
Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance ...
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https://www.dovepress.com/effects-of-switching-from-olanzapine-to-aripiprazole-on-the-metabolic--peer-reviewed-fulltext-article-NDT
Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance ...
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72
Olanzapine (Oral Route) - Mayo Clinic
https://www.mayoclinic.org/drugs./olanzapine./drg-20071350?p=1
Olanzapine may also be used together with fluoxetine to treat depression that is a ... Phenylketonuria (PKU, a genetic disease of metabolism)—The orally ...
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https://www.mayoclinic.org/drugs./olanzapine./drg-20071350?p=1
Olanzapine may also be used together with fluoxetine to treat depression that is a ... Phenylketonuria (PKU, a genetic disease of metabolism)—The orally ...
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73
Effect of Telmisartan on Olanzapine Induced Metabolic ...
https://www.jofem.org/index.php/jofem/article/view/100/0
... metabolism. Thus the objective of the present study was to evaluate the effect of telmisartan and additional influence of menopause status on olanzapine ...
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https://www.jofem.org/index.php/jofem/article/view/100/0
... metabolism. Thus the objective of the present study was to evaluate the effect of telmisartan and additional influence of menopause status on olanzapine ...
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74
Olanzapine-Associated Rhabdomyolysis: A Case Report
https://www.cureus.com/articles/48439-olanzapine-associated-rhabdomyolysis-a-case-report
Apart from glucuronidation, olanzapine undergoes oxidative hepatic metabolism resulting in the formation of 4'-N-desmethyl-olanzapine, ...
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https://www.cureus.com/articles/48439-olanzapine-associated-rhabdomyolysis-a-case-report
Apart from glucuronidation, olanzapine undergoes oxidative hepatic metabolism resulting in the formation of 4'-N-desmethyl-olanzapine, ...
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75
Smoking-and-caffeine-effects-on-antipsychotics.pdf - WA Health
https://ww2.health.wa.gov.au/~/media/Files/Corporate/general-documents/WATAG/WAPDC/Smoking-and-caffeine-effects-on-antipsychotics.pdf
Clozapine and olanzapine. Cigarette smoking significantly induces the metabolism of both clozapine and olanzapine resulting in lower plasma concentrations.3 ...
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https://ww2.health.wa.gov.au/~/media/Files/Corporate/general-documents/WATAG/WAPDC/Smoking-and-caffeine-effects-on-antipsychotics.pdf
Clozapine and olanzapine. Cigarette smoking significantly induces the metabolism of both clozapine and olanzapine resulting in lower plasma concentrations.3 ...
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76
Interactions between Antiepileptics and Second-Generation ...
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1038&context=psychiatry_facpub
SGAPs dependent on CYP3A4 (aripiprazole, lurasidone, quetiapine and risperidone) or UGTs (asenapine and olanzapine) for their metabolism.
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https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1038&context=psychiatry_facpub
SGAPs dependent on CYP3A4 (aripiprazole, lurasidone, quetiapine and risperidone) or UGTs (asenapine and olanzapine) for their metabolism.
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77
Lack of Pharmacokinetic Interaction between Antipsychotics ...
https://www.omicsonline.org/open-access/lack-of-pharmacokinetic-interaction-between-antipsychotics-quetiapine-clozapine-and-olanzapine-and-the-betablockers-metoprolol-pro-2155-9872-1000387-95453.html
Antipsychotics and beta-blockers are metabolized by the same cytochrome-P450 (CYP)-isoenzymes, which are inhibited by representatives of both substance classes.
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https://www.omicsonline.org/open-access/lack-of-pharmacokinetic-interaction-between-antipsychotics-quetiapine-clozapine-and-olanzapine-and-the-betablockers-metoprolol-pro-2155-9872-1000387-95453.html
Antipsychotics and beta-blockers are metabolized by the same cytochrome-P450 (CYP)-isoenzymes, which are inhibited by representatives of both substance classes.
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78
Olanzapine-Induced Hyperphagia and Weight Gain Associate ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020571
Recent investigations have also linked antipsychotic drug treatment to alterations in hypothalamic lipid metabolism. In an acute study on mice, ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020571
Recent investigations have also linked antipsychotic drug treatment to alterations in hypothalamic lipid metabolism. In an acute study on mice, ...
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79
In vitro effect of antipsychotics on brain energy metabolism ...
https://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/in-vitro-effect-of-antipsychotics-on-brain-energy-metabolism-parameters-in-the-brain-of-rats/D9A7540ADE8D3625CF5563E69ABFEE22
Our results showed that olanzapine and aripriprazole increased the activities of respiratory chain complexes. On the other hand, complex IV activity was ...
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https://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/in-vitro-effect-of-antipsychotics-on-brain-energy-metabolism-parameters-in-the-brain-of-rats/D9A7540ADE8D3625CF5563E69ABFEE22
Our results showed that olanzapine and aripriprazole increased the activities of respiratory chain complexes. On the other hand, complex IV activity was ...
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80
Olanzapine | Psychology Wiki - Fandom
https://psychology.fandom.com/wiki/Olanzapine
Olanzapine is metabolized by the Cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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https://psychology.fandom.com/wiki/Olanzapine
Olanzapine is metabolized by the Cytochrome P450 system isoenzymes 1A2 and 2D6 (minor pathway). Drug metabolism may be increased or decreased by agents that ...
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81
Olanzapine - Side Effects, Uses, Dosage, Overdose ... - RxWiki
https://www.rxwiki.com/olanzapine
Olanzapine - Get up-to-date information on Olanzapine side effects, uses, dosage, ... Olanzapine may be excreted in human breast milk.
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https://www.rxwiki.com/olanzapine
Olanzapine - Get up-to-date information on Olanzapine side effects, uses, dosage, ... Olanzapine may be excreted in human breast milk.
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82
Zyprexa Side Effects, Uses & Gene-Drug Interaction - GeneSight
https://genesight.com/product/medications-zyprexa-olanzapine/
... potential for slowed metabolism. (2.1); Olanzapine may be given without regard to meals. (2.1). ZYPREXA and Fluoxetine in Combination:.
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https://genesight.com/product/medications-zyprexa-olanzapine/
... potential for slowed metabolism. (2.1); Olanzapine may be given without regard to meals. (2.1). ZYPREXA and Fluoxetine in Combination:.
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83
Olanzapine - Mechanism, side effects and precautions
https://www.youtube.com/watch?v=gt2U5RVten4
Mar 24, 2021
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https://www.youtube.com/watch?v=gt2U5RVten4
Mar 24, 2021
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84
OLANZapine: Dosage, Mechanism/Onset of Action, Half-Life
https://www.medicine.com/drug/olanzapine/hcp
Note: In patients who are medically ill, at risk for postural hypotension, or may metabolize more slowly (eg, nonsmoking, female, ≥65 years of age), a low ...
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https://www.medicine.com/drug/olanzapine/hcp
Note: In patients who are medically ill, at risk for postural hypotension, or may metabolize more slowly (eg, nonsmoking, female, ≥65 years of age), a low ...
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85
Primidone Pharmacology
https://www.reallifepharmacology.com/primidone-pharmacology/
It is metabolized into its active metabolites by CYP2C9, CYP2C19, ... alprazolam, and olanzapine should be monitored more closely.
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https://www.reallifepharmacology.com/primidone-pharmacology/
It is metabolized into its active metabolites by CYP2C9, CYP2C19, ... alprazolam, and olanzapine should be monitored more closely.
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86
Psychotropic substances are poisoning pets - DVM360
https://www.dvm360.com/view/psychotropic-substances-are-poisoning-pets
For ER products, metabolism is slower, and decontamination can be ... Lithium, lamotrigine, and antipsychotic drugs such as olanzapine, ...
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https://www.dvm360.com/view/psychotropic-substances-are-poisoning-pets
For ER products, metabolism is slower, and decontamination can be ... Lithium, lamotrigine, and antipsychotic drugs such as olanzapine, ...
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87
Olanzapine | Atypical Antipsychotic Use & Side ... - YoungMinds
https://www.youngminds.org.uk/young-person/medications/olanzapine/
Olanzapine is an atypical antipsychotic used to treat bipolar disorder, schizophrenia and psychosis. Find out more about its use and side effects.
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https://www.youngminds.org.uk/young-person/medications/olanzapine/
Olanzapine is an atypical antipsychotic used to treat bipolar disorder, schizophrenia and psychosis. Find out more about its use and side effects.
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88
Constipation; Symptoms, Causes, Treatment & Prevention
https://my.clevelandclinic.org/health/diseases/4059-constipation
Older people tend to be less active, have a slower metabolism and less muscle ... like clozapine (Clozaril®) and olanzapine (Zyprexa®).
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https://my.clevelandclinic.org/health/diseases/4059-constipation
Older people tend to be less active, have a slower metabolism and less muscle ... like clozapine (Clozaril®) and olanzapine (Zyprexa®).
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89
Transcript: Oxcarbazepine Use, Choosing an Atypical ...
https://www.hmpgloballearningnetwork.com/site/pcn/transcript-oxcarbazepine-use-choosing-atypical-antipsychotic-bipolar-treatment
... we'll use them more sedating, atypical antipsychotic, olanzapine, ... remember, carbamazepine speeds up metabolism of everything.
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https://www.hmpgloballearningnetwork.com/site/pcn/transcript-oxcarbazepine-use-choosing-atypical-antipsychotic-bipolar-treatment
... we'll use them more sedating, atypical antipsychotic, olanzapine, ... remember, carbamazepine speeds up metabolism of everything.
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90
Gabapentin potentiates adderall
https://hockenheim-fuer-klimaschutz.de/gabapentin-potentiates-adderall.html
Катэна. 1) • Carbamazepine:Increased clearance of olanzapine. ... opioid drug by drinking grapefruit juice can alter the drug's metabolism. com For any help ...
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https://hockenheim-fuer-klimaschutz.de/gabapentin-potentiates-adderall.html
Катэна. 1) • Carbamazepine:Increased clearance of olanzapine. ... opioid drug by drinking grapefruit juice can alter the drug's metabolism. com For any help ...
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91
Weight Gain: Symptoms, Causes, and Treatment
https://www.verywellhealth.com/weight-gain-5524770
Aging: As we get older, our metabolism slows down. ... Examples include Abilify (aripiprazole), Zyprexa (olanzapine), and Seroquel ...
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https://www.verywellhealth.com/weight-gain-5524770
Aging: As we get older, our metabolism slows down. ... Examples include Abilify (aripiprazole), Zyprexa (olanzapine), and Seroquel ...
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92
Vilazodone dose. The initial dose of Viibryd is usually 10 mg ...
http://dancingmice.net/mdkday/vilazodone-dose.html
... olanzapine, immediate release quetiapine fumarate, ziprasidone, aripiprazole, ... Elimination of vilazodone is primarily by hepatic metabolism with a ...
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http://dancingmice.net/mdkday/vilazodone-dose.html
... olanzapine, immediate release quetiapine fumarate, ziprasidone, aripiprazole, ... Elimination of vilazodone is primarily by hepatic metabolism with a ...
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93
[Safe & Effective] Appetite Suppressant Over-the-counter ...
https://www.jewishledger.com/loss/thrive-wb4Rwjhst-weight-loss-results/
A separate study published in the journal Metabolism found that ... cyproheptadine, and olanzapine Hormonal therapy Megestrol acetate is a ...
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https://www.jewishledger.com/loss/thrive-wb4Rwjhst-weight-loss-results/
A separate study published in the journal Metabolism found that ... cyproheptadine, and olanzapine Hormonal therapy Megestrol acetate is a ...
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94
5 Best Male Enhancement Pills and Treatments of 2022
https://www.healthline.com/health/mens-health/male-enhancement-pills
Ginkgo biloba extract. This ingredient may change the effectiveness of medications that affect the nervous system, such as clozapine, alprazolam, olanzapine. It ...
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Ginkgo biloba extract. This ingredient may change the effectiveness of medications that affect the nervous system, such as clozapine, alprazolam, olanzapine. It ...
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